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mouse kidney epithelial cell line  (ATCC)


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    ATCC mouse kidney epithelial cell line
    The mechanism diagram of the study. Upregulated ATF3 in damaged tubular <t>epithelial</t> cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.
    Mouse Kidney Epithelial Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 209 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+epithelial+kidney+cell+line+tcmk+1/TCMK-1/pmc12781174-59-0-20
    Average 96 stars, based on 209 article reviews
    mouse kidney epithelial cell line - by Bioz Stars, 2026-09
    96/100 stars

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    1) Product Images from "ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming"

    Article Title: ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming

    Journal: International Journal of Biological Sciences

    doi: 10.7150/ijbs.125062

    The mechanism diagram of the study. Upregulated ATF3 in damaged tubular epithelial cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.
    Figure Legend Snippet: The mechanism diagram of the study. Upregulated ATF3 in damaged tubular epithelial cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.

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    Related Articles

    other:

    Article Title: Oleanolic Acid Acetate Alleviates Cisplatin-Induced Nephrotoxicity via Inhibition of Apoptosis and Necroptosis In Vitro and In Vivo.
    Article Snippet: The mouse epithelial kidney cell line TCMK-1 (CCL-139) was purchased from the American Type Culture Collection (Manassas, VA, USA).

    Article Title: Oleanolic Acid Acetate Alleviates Cisplatin-Induced Nephrotoxicity via Inhibition of Apoptosis and Necroptosis In Vitro and In Vivo
    Article Snippet: The mouse epithelial kidney cell line TCMK-1 (CCL-139) was purchased from the American Type Culture Collection (Manassas, VA, USA).

    Cell Culture:

    Article Title: The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis
    Article Snippet: .. Mouse epithelial kidney cell line TCMK-1 (cat no. CCL-139, Manassas, VA, USA) and Caki-1 (cat no. HTB-46) was obtained from ATCC and was cultured in Eagle’s minimal essential medium (EMEM; Lonza, Basel, Switzerland) supplemented with 10% fetal bovine serum (FBS). .. The RPTEC/TERT1 (ATCC) cell line (passages 7–17) was cultured in DMEM:F12 medium (ATCC) supplemented with the components of the hTERT RPTEC Growth Kit (ATCC) and G418 at a final concentration of 0.1 mg/ml (Sigma).

    Article Title: The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis.
    Article Snippet: .. Mouse epithelial kidney cell line TCMK-1 (cat no. CCL139, Manassas, VA, USA) and Caki-1 (cat no. HTB-46) was obtained from ATCC and was cultured in Eagle’s minimal essential medium (EMEM; Lonza, Basel, Switzerland) supplemented with 10% fetal bovine serum (FBS). .. The RPTEC/TERT1 (ATCC) cell line (passages 7–17) was cultured in DMEM:F12 medium (ATCC) supplemented with the components of the hTERT RPTEC Growth Kit (ATCC) and G418 at a final concentration of 0.1 mg/ml (Sigma).



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    Image Search Results


    The mechanism diagram of the study. Upregulated ATF3 in damaged tubular epithelial cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.

    Journal: International Journal of Biological Sciences

    Article Title: ATF3 aggravates kidney fibrosis via HDAC6-dependent epigenetic reprogramming

    doi: 10.7150/ijbs.125062

    Figure Lengend Snippet: The mechanism diagram of the study. Upregulated ATF3 in damaged tubular epithelial cells (TECs) promotes the progression of kidney fibrosis. In TECs, under homeostatic conditions, SMAD7 transcripts with histone 3 lysine 14 acetylation and histone opening. Under fibrotic conditions, upregulated ATF3 recruits HDAC6 to the SMAD7 promoter, eradicating histone 3 lysine 14 acetylation (H3K14ac) and diminishing SMAD7 transcription, thus activates TGF-β1/Smad3 signaling and aggravates kidney fibrosis.

    Article Snippet: Mouse kidney epithelial cell line (TCMK-1), HEK 293T cells and rat renal interstitial fibroblasts (NRK-49F) cells were purchased from the American Type Culture Collection (Manassas, VA) and were cultured in DMEM (Sigma-Aldrich) containing 10% fetal bovine serum (FBS), at 37°C, 5% CO2, 95% air.

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